Looking to build upon their recent 3-2 victory, Guyana got underway to a disappointing start as current free agent Rubio Rubín gave Guatemala the lead with ten minutes on the clock.
With the match seemingly set to end level on aggregate, La Azul y Blanco went on to double their lead, and go ahead 4-3 on aggregate, Comunicaciones attacker Erick Lemus struck the ball home.
The final action of note in the penalty area came in the form of a red card as Guyana 'keeper Quillan Roberts was dismissed with six minutes of normal time remaining, the Golden Jaguars unable to open their account on a frustrating evening.