The Saddlers will take on Mark Robins’ Sky Blues at Birmingham City's St Andrew’s and are in desperate need of a positive result having only won one of their seven games so far this season.
Mansfield-born Clarke is likely to offer starts to a few of his fringe players with the likes of Jake Rose, Shay Facey, Wes McDonald, and Alfie Bates yet to earn a league start so far this season.
While the likes of Zak Jules, Jack Kiersey and new recruit Rory Gaffney, who joined the club at the weekend, are also eager for a chance to impress as they battle it out for a starting spot.
Speaking via the Express & Star, Darrell said; "There will be some changes. There are some players who haven’t made their debuts yet because I’m trying to settle it all down.
"It’s about getting the balance right and deciding when they are ready to come in and make a difference. It is very difficult as a manager to keep swinging different players in and swinging all the balls about.
"You have got to be careful how many changes you make when it’s a new, developing group. Football games are won on partnerships – partnerships on the pitch.
"You want to build those partnerships. But we are still looking for that winning formula. We’ve got a team and squad that can mix it up and is adaptable to different formations and change. And we will get there."
Clarke, who has seen his side struggle to score goals, is yet to name the same starting eleven for two games in a row and admitted that he doesn’t yet know his best team.
Darrell continued; "It is but I have had some players unavailable through injury as well.
"But I do treat every game as an individual project. It’s a different game, different mentality. We’ve had a bad start to the season with a new group of players. Let’s move on and try and beat Coventry."