There are several teams expected to mount a challenge on the title this season with the likes of Bradford City, Salford City, Mansfield Town, and Plymouth Argyle backed to battle it out at the top of the table.
Following their relegation to the fourth-tier of English football Darrell Clarke's Saddlers are among the sides expected to mount a challenge in and around the Play-Off places with punters able to back the team with odds of 4/1.
This weekend's opponents Northampton Town, who are managed by Keith Curle, are fancied to be among the promotion-chasers this season and can be backed with odds of 3/1.
Meanwhile, fellow relegation sufferers Bradford City, who have former Saddlers Richard O'Donnell and Zeli Ismail among their ranks, are the current (narrow) favourites to take the title with odds of 13/8.
Last season's National League Play-Off winners Salford City are second favourites for promotion, with the 'Class of 92' backed side available at 15/8.
Mansfield Town and Plymouth Argyle can be found at 9/4, whilst Glanford Park-based Scunthorpe United are available at 5/2 with Sky Bet giving them an outside chance of reaching League One at the end of the season.
Sky Bet: League Two Promotion Odds
Bradford City - 13/8
Salford City - 15/8
Mansfield Town - 9/4
Plymouth Argyle - 9/4
Scunthorpe United - 5/2
Northampton Town - 3/1
Colchester United - 7/2
Forest Green Rovers - 7/2
Swindon Town - 7/2
Leyton Orient - 4/1
Walsall - 4/1
Exeter City - 5/1
Newport County - 5/1
Carlisle United - 6/1
Crewe Alexandra - 6/1
Oldham Athletic - 6/1
Stevenage - 8/1
Port Vale - 9/1
Cambridge United - 10/1
Cheltenham Town - 10/1
Grimsby Town - 12/1
Crawley Town 16/1
Morecambe - 20/1
Macclesfield Town - 22/1