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Leyton Orient will be without veteran striker Kevin Lisbie, who has scored 12 goals this season. He missed the draw with Sheffield United last weekend after picking up an ankle injury in training, Shaun Batt is likely to continue in attack.
Boss Russell Slade could decide to give back-up goalkeeper Jake Larkins and fellow youngsters Yohann Lasimant and Johnny Gorman run-outs after they played in the first-round win over Southport.
Walsall continue to boast a fully-fit squad, The Saddlers have enjoyed an empty treatment room for several weeks and boss Dean Smith will be hoping that remains the case as the club head into the hectic festive period.
In terms of head-to-head, Leyton Orient are in the lead with twenty-eight wins versus Walsall's twenty-two, there have also been eighteen draws. Walsall haven't beaten their opponents won one of the last five between the two.